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Title:

Comparison of pretherapeutic and posttherapeutic expression levels of chemotherapy-associated genes in adenocarcinomas of the esophagus treated by 5-fluorouracil- and cisplatin-based neoadjuvant chemotherapy.

Document type:
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Langer, R; Specht, K; Becker, K; Ewald, P; Ott, K; Lordick, F; Siewert, JR; Höfler, H
Abstract:
We analyzed expression of genes associated with metabolism of chemotherapeutic drugs in locally advanced esophageal adenocarcinomas before and after neoadjuvant chemotherapy to study whether there is a change in gene expression induced by chemotherapy and whether such changes are associated with tumor response or nonresponse. We included 21 patients with locally advanced esophageal adenocarcinomas treated by cisplatin- and 5-fluorouracil (5-FU)-based neoadjuvant chemotherapy before surgery. Mess...     »
Journal title abbreviation:
Am J Clin Pathol
Year:
2007
Journal volume:
128
Journal issue:
2
Pages contribution:
191-7
Language:
eng
Fulltext / DOI:
doi:10.1309/1U6X4L9XFJLJV940
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/17638652
Print-ISSN:
0002-9173
TUM Institution:
Chirurgische Klinik und Poliklinik; III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie); Institut für Allgemeine Pathologie und Pathologische Anatomie
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