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Title:

Pharmacological inhibition of EGFR tyrosine kinase affects ILK-mediated cellular radiosensitization in vitro.

Document type:
Journal Article; Article
Author(s):
Eke, I; Sandfort, V; Storch, K; Baumann, M; Röper, B; Cordes, N
Abstract:
Purpose: Integrin-linked kinase (ILK) mediates signals from beta integrins and links integrins to epidermal growth factor receptor (EGFR). Previous studies have identified an antisurvival effect of ILK in irradiated cells. The aim of this study was to evaluate the role of EGFR tyrosine kinase (tk) activity for ILK-mediated radiosensitization. Materials and methods: Human FaDu squamous cell carcinoma (SCC) cells stably transfected with hyperactive ILK (ILK-hk) and ILK(fl/fl) and ILK(-/-) mouse fi...     »
Journal title abbreviation:
Int J Radiat Biol
Year:
2007
Journal volume:
83
Journal issue:
11
Pages contribution:
793-802
Language:
eng
Fulltext / DOI:
doi:10.1080/09553000701727549
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/18058367
Print-ISSN:
0955-3002
TUM Institution:
Klinik und Poliklinik für RadioOnkologie und Strahlentherapie
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