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Titel:

Pharmacological inhibition of EGFR tyrosine kinase affects ILK-mediated cellular radiosensitization in vitro.

Dokumenttyp:
Journal Article; Article
Autor(en):
Eke, I; Sandfort, V; Storch, K; Baumann, M; Röper, B; Cordes, N
Abstract:
Purpose: Integrin-linked kinase (ILK) mediates signals from beta integrins and links integrins to epidermal growth factor receptor (EGFR). Previous studies have identified an antisurvival effect of ILK in irradiated cells. The aim of this study was to evaluate the role of EGFR tyrosine kinase (tk) activity for ILK-mediated radiosensitization. Materials and methods: Human FaDu squamous cell carcinoma (SCC) cells stably transfected with hyperactive ILK (ILK-hk) and ILK(fl/fl) and ILK(-/-) mouse fi...     »
Zeitschriftentitel:
Int J Radiat Biol
Jahr:
2007
Band / Volume:
83
Heft / Issue:
11
Seitenangaben Beitrag:
793-802
Sprache:
eng
Volltext / DOI:
doi:10.1080/09553000701727549
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/18058367
Print-ISSN:
0955-3002
TUM Einrichtung:
Klinik und Poliklinik für RadioOnkologie und Strahlentherapie
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