Association of lipopolysaccharide-binding protein and coronary artery disease in men.

Lepper, PM; Schumann, C; Triantafilou, K; Rasche, FM; Schuster, T; Frank, H; Schneider, EM; Triantafilou, M; von Eynatten, M

doi:10.1016/j.jacc.2007.02.070

2007

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Title:: Association of lipopolysaccharide-binding protein and coronary artery disease in men.
Document type:: Journal Article
Author(s):: Lepper, PM; Schumann, C; Triantafilou, K; Rasche, FM; Schuster, T; Frank, H; Schneider, EM; Triantafilou, M; von Eynatten, M
Abstract:: OBJECTIVES: In this study we tested the hypothesis that lipopolysaccharide-binding protein (LBP) might be able to be used as a biomarker for coronary artery disease (CAD). BACKGROUND: The mechanisms by which the innate immune recognition of pathogens could lead to atherosclerosis remain unclear. Lipopolysaccharide-binding protein is the first protein to encounter lipopolysaccharide and to deliver it to its cellular targets, toll-like receptors; therefore, its presence might be a reliable biomarker that indicates activation of innate immune responses. METHODS: A total of 247 men undergoing elective coronary angiography were studied, and the extent of coronary atherosclerosis was assessed by 2 established scores: "extent score" and "severity score." Levels of LBP, markers of inflammation, and traditional risk factors for CAD were assessed. RESULTS: Serum LBP concentration was significantly increased in 172 patients with angiographically confirmed CAD compared with 75 individuals without coronary atherosclerosis (20.6 +/- 8.7 pg/ml vs. 17.1 +/- 6.0 pg/ml, respectively; p = 0.002). Moreover in multivariable logistic regression analyses, adjusted for established cardiovascular risk factors and markers of systemic inflammation, LBP was a significant and independent predictor of prevalent CAD (p < 0.05 in all models). CONCLUSIONS: Lipopolysaccharide-binding protein might serve as a novel marker for CAD in men. The present results underlie the potential importance of innate immune mechanisms for CAD. Further studies are warranted to bolster the data and to identify pathogenetic links between innate immune system activation and atherosclerosis.
Journal title abbreviation:: J Am Coll Cardiol
Year:: 2007
Journal volume:: 50
Journal issue:: 1
Pages contribution:: 25-31
Language:: eng
Fulltext / DOI:: doi:10.1016/j.jacc.2007.02.070
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/17601541
Print-ISSN:: 0735-1097
TUM Institution:: Fachgebiet Nephrologie (Prof. Heemann); Institut für Medizinische Statistik und Epidemiologie
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mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Klinik und Poliklinik für Innere Medizin II, Gastroenterologie (Prof. Schmid)Abteilung für Nephrologie (Prof. Heemann)Professur für Nephrologie (Prof. Heemann)2007

mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Institut für KI und Informatik in der Medizin (Prof. Rückert)2007