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Title:

Defining 'response' in antipsychotic drug trials: recommendations for the use of scale-derived cutoffs.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Leucht, S; Davis, JM; Engel, RR; Kane, JM; Wagenpfeil, S
Abstract:
Scale-derived cutoff points are frequently used to define 'response' in antipsychotic drug trials. This procedure is useful, because responder rates can be understood more intuitively than a difference in means of rating scales. As various definitions of response have been used, we examined original participant data to assess whether the choice of the Brief Psychiatric Rating Scale-based response cutoff had an impact on the results of seven (n=1870) antipsychotic drug trials in schizophrenia. We...     »
Journal title abbreviation:
Neuropsychopharmacology
Year:
2007
Journal volume:
32
Journal issue:
9
Pages contribution:
1903-10
Language:
eng
Fulltext / DOI:
doi:10.1038/sj.npp.1301325
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/17287825
Print-ISSN:
0893-133X
TUM Institution:
Institut für Medizinische Statistik und Epidemiologie; Klinik und Poliklinik für Psychiatrie und Psychotherapie
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