User: Guest  Login
Title:

Expression of the mitotic checkpoint gene MAD2L2 has prognostic significance in colon cancer.

Document type:
Journal Article
Author(s):
Rimkus, C; Friederichs, J; Rosenberg, R; Holzmann, B; Siewert, JR; Janssen, KP
Abstract:
Aneuploidy and genetic instability are a hallmark of colorectal cancer and other solid tumors, and they are thought to enhance tumor progression. The gene MAD2L2 (mitotic arrest deficient 2-like 2) encodes the spindle checkpoint protein MAD2L2 (or MAD2B), a key component of a surveillance system that delays anaphase until all chromosomes are correctly oriented. Defects in this mitotic checkpoint are known to contribute to genetic instability, i.e., numerical and structural aberrations of chromos...     »
Journal title abbreviation:
Int J Cancer
Year:
2007
Journal volume:
120
Journal issue:
1
Pages contribution:
207-11
Language:
eng
Fulltext / DOI:
doi:10.1002/ijc.22155
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/17044027
Print-ISSN:
0020-7136
TUM Institution:
Chirurgische Klinik und Poliklinik
 BibTeX