User: Guest  Login
More Searchfields
Simple search
Title:

Inhibition of the tumor-associated urokinase-type plasminogen activation system: effects of high-level synthesis of soluble urokinase receptor in ovarian and breast cancer cells in vitro and in vivo.

Document type:
Journal Article; Review
Author(s):
Magdolen, V; Kruger, A; Sato, S; Nagel, J; Sperl, S; Reuning, U; Rettenberger, P; Magdolen, U; Schmitt, M
Abstract:
Tumor cell invasion and metastasis depend on the coordinated and temporal expression of proteolytic enzymes to degrade the surrounding extracellular matrix and of adhesion molecules to remodel cell-cell and/or cell-matrix attachments. The tumor cell-associated urokinase-type plasminogen activator system, consisting of the serine protease uPA, its substrate plasminogen, its membrane-bound receptor uPAR, as well as its inhibitors PAI-1 and PAI-2, plays an important role in these pericellular proce...     »
Journal title abbreviation:
Recent Results Cancer Res
Year:
2003
Journal volume:
162
Pages contribution:
43-63
Language:
eng
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/12790320
Print-ISSN:
0080-0015
TUM Institution:
Frauenklinik und Poliklinik; Institut für Experimentelle Onkologie und Therapieforschung
 BibTeX