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Titel:

Inhibition of the tumor-associated urokinase-type plasminogen activation system: effects of high-level synthesis of soluble urokinase receptor in ovarian and breast cancer cells in vitro and in vivo.

Dokumenttyp:
Journal Article; Review
Autor(en):
Magdolen, V; Kruger, A; Sato, S; Nagel, J; Sperl, S; Reuning, U; Rettenberger, P; Magdolen, U; Schmitt, M
Abstract:
Tumor cell invasion and metastasis depend on the coordinated and temporal expression of proteolytic enzymes to degrade the surrounding extracellular matrix and of adhesion molecules to remodel cell-cell and/or cell-matrix attachments. The tumor cell-associated urokinase-type plasminogen activator system, consisting of the serine protease uPA, its substrate plasminogen, its membrane-bound receptor uPAR, as well as its inhibitors PAI-1 and PAI-2, plays an important role in these pericellular proce...     »
Zeitschriftentitel:
Recent Results Cancer Res
Jahr:
2003
Band / Volume:
162
Seitenangaben Beitrag:
43-63
Sprache:
eng
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/12790320
Print-ISSN:
0080-0015
TUM Einrichtung:
Frauenklinik und Poliklinik; Institut für Experimentelle Onkologie und Therapieforschung
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