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Title:

Influence of tumor-associated E-cadherin mutations on tumorigenicity and metastasis.

Document type:
Journal Article; Article
Author(s):
Kremer, M; Quintanilla-Martinez, L; Fuchs, M; Gamboa-Dominguez, A; Haye, S; Kalthoff, H; Rosivatz, E; Hermannstädter, C; Busch, R; Höfler, H; Luber, B
Abstract:
In this study, we investigated whether tumor-associated E-cadherin mutations impair the tumor-suppressive function of the cell adhesion molecule and influence metastasis formation in a severe combined immunodeficiency mouse model. The investigated E-cadherin mutations were in frame deletions of exons 8 (del 8) or 9 (del 9) and a point mutation in exon 8 (p8). Transfected human MDA-MB-435S carcinoma cells stably expressing wild-type (wt) or mutant E-cadherin were injected into the mouse mammary f...     »
Journal title abbreviation:
Carcinogenesis
Year:
2003
Journal volume:
24
Journal issue:
12
Pages contribution:
1879-86
Language:
eng
Fulltext / DOI:
doi:10.1093/carcin/bgg148
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/12949051
Print-ISSN:
0143-3334
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie; Institut für Medizinische Statistik und Epidemiologie
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