User: Guest  Login
More Searchfields
Simple search
Title:

Point mutations in or near the antigen-binding groove of HLA-DR3 implicate class II-associated invariant chain peptide affinity as a constraint on MHC class II polymorphism.

Document type:
Journal Article
Author(s):
Doebele, RC; Pashine, A; Liu, W; Zaller, DM; Belmares, M; Busch, R; Mellins, ED
Abstract:
During maturation of MHC II molecules, newly synthesized and assembled complexes of MHC II alphabeta dimers with invariant chain (Ii) are targeted to endosomes, where Ii is proteolyzed, leaving remnant class II-associated Ii peptides (CLIP) in the MHC II peptide binding groove. CLIP must be released, usually with assistance from the endosomal MHC II peptide exchange factor, HLA-DM, before MHC II molecules can bind endosomal peptides. Structural factors that control rates of CLIP release remain p...     »
Journal title abbreviation:
J Immunol
Year:
2003
Journal volume:
170
Journal issue:
9
Pages contribution:
4683-92
Language:
eng
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/12707347
Print-ISSN:
0022-1767
TUM Institution:
Institut für Medizinische Statistik und Epidemiologie
 BibTeX