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Title:

Transcriptional inhibition of interleukin-8 expression in tumor necrosis factor-tolerant cells: evidence for involvement of C/EBP beta.

Document type:
Journal Article; Article
Author(s):
Weber, M; Sydlik, C; Quirling, M; Nothdurfter, C; Zwergal, A; Heiss, P; Bell, S; Neumeier, D; Ziegler-Heitbrock, HW; Brand, K
Abstract:
There is some evidence that the potent cytokine tumor necrosis factor (TNF) is able to induce tolerance after repeated stimulation of cells. To investigate the molecular mechanisms mediating this phenomenon, the expression of interleukin-8 (IL-8), which is regulated by transcription factors NF-kappaB and C/EBPbeta, was monitored under TNF tolerance conditions. Pretreatment of monocytic cells for 72 h with low TNF doses inhibited TNF-induced (restimulation with a high dose) IL-8 promoter-dependen...     »
Journal title abbreviation:
J Biol Chem
Year:
2003
Journal volume:
278
Journal issue:
26
Pages contribution:
23586-93
Language:
eng
Fulltext / DOI:
doi:10.1074/jbc.M211646200
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/12707271
Print-ISSN:
0021-9258
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie
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