User: Guest  Login
Less Searchfields
Simple search
Title:

High-speed genotyping of CYP1A2*1F mutation with fluorescent hybridization probes using the LightCycler.

Document type:
Journal Article; Article
Author(s):
Popp, J; Messner, B; Steimer, W
Abstract:
The polymorphism CYP1A2*1F of the cytochrome 1A2 gene affects the inducibility of this cytochrome, which is involved in the metabolism of many commonly used drugs. We developed a rapid-cycle polymerase chain reaction (PCR) and fluorescent probe melting curve analysis on the LightCycler instrument for identification of this mutation. This new method was confirmed by genotyping 101 samples in parallel to restriction enzyme digestion. The 100% concordance of both methods showed the reliability of o...     »
Journal title abbreviation:
Pharmacogenomics
Year:
2003
Journal volume:
4
Journal issue:
5
Pages contribution:
643-6
Language:
eng
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/12943470
Print-ISSN:
1462-2416
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie
 BibTeX