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Title:

Optimized strategy for rapid cytochrome P450 2D6 genotyping by real-time long PCR.

Document type:
Journal Article; Article
Author(s):
Müller, B; Zopf, K; Bachofer, J; Steimer, W
Abstract:
BACKGROUND: Because of genetic polymorphisms, cytochrome P450 2D6 (Cyp2D6) activity in humans varies widely and alters the metabolism of commonly used drugs such as antidepressants, neuroleptics, and cardioactive agents. Severe adverse effects or resistance to therapy may result. METHODS: We performed long PCR on the LightCycler(TM) and used the product as a template for a previously validated multiplex PCR that examines the *3, *4, *6, *7, and *8 alleles of Cyp2D6. We used real-time PCR to iden...     »
Journal title abbreviation:
Clin Chem
Year:
2003
Journal volume:
49
Journal issue:
10
Pages contribution:
1624-31
Language:
eng
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/14500587
Print-ISSN:
0009-9147
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie
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