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Titel:

High-speed genotyping of CYP1A2*1F mutation with fluorescent hybridization probes using the LightCycler.

Dokumenttyp:
Journal Article; Article
Autor(en):
Popp, J; Messner, B; Steimer, W
Abstract:
The polymorphism CYP1A2*1F of the cytochrome 1A2 gene affects the inducibility of this cytochrome, which is involved in the metabolism of many commonly used drugs. We developed a rapid-cycle polymerase chain reaction (PCR) and fluorescent probe melting curve analysis on the LightCycler instrument for identification of this mutation. This new method was confirmed by genotyping 101 samples in parallel to restriction enzyme digestion. The 100% concordance of both methods showed the reliability of o...     »
Zeitschriftentitel:
Pharmacogenomics
Jahr:
2003
Band / Volume:
4
Heft / Issue:
5
Seitenangaben Beitrag:
643-6
Sprache:
eng
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/12943470
Print-ISSN:
1462-2416
TUM Einrichtung:
Institut für Klinische Chemie und Pathobiochemie
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