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Titel:

Syntheses and ligand-binding studies of 1 alpha- and 17 alpha-aminoalkyl dihydrotestosterone derivatives to human sex hormone-binding globulin.

Dokumenttyp:
Journal Article; Article
Autor(en):
Hauptmann, H; Metzger, J; Schnitzbauer, A; Cuilleron, CY; Mappus, E; Luppa, PB
Abstract:
We report on the syntheses of 1 alpha- and 17 alpha-aminoalkyl dihydrotestosterone (DHT) derivatives and the particularly high binding affinity of the 1 alpha-aminohexyl ligand for human sex hormone-binding globulin (SHBG). The two 17 alpha-aminopropyl-17 beta-hydroxy-5 alpha-androstan-3-one (1) and 17 alpha-aminocaproylamidoethyl-17 beta-hydroxy-5 alpha-androstan-3-one (2) derivatives were synthesized via a 17beta-spirooxirane intermediate in high yields. The 1 alpha-aminohexyl-17 beta-hydroxy-...     »
Zeitschriftentitel:
Steroids
Jahr:
2003
Band / Volume:
68
Heft / Issue:
7-8
Seitenangaben Beitrag:
629-39
Sprache:
eng
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/12957668
Print-ISSN:
0039-128X
TUM Einrichtung:
Institut für Klinische Chemie und Pathobiochemie
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