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Titel:

Transcriptional inhibition of interleukin-8 expression in tumor necrosis factor-tolerant cells: evidence for involvement of C/EBP beta.

Dokumenttyp:
Journal Article; Article
Autor(en):
Weber, M; Sydlik, C; Quirling, M; Nothdurfter, C; Zwergal, A; Heiss, P; Bell, S; Neumeier, D; Ziegler-Heitbrock, HW; Brand, K
Abstract:
There is some evidence that the potent cytokine tumor necrosis factor (TNF) is able to induce tolerance after repeated stimulation of cells. To investigate the molecular mechanisms mediating this phenomenon, the expression of interleukin-8 (IL-8), which is regulated by transcription factors NF-kappaB and C/EBPbeta, was monitored under TNF tolerance conditions. Pretreatment of monocytic cells for 72 h with low TNF doses inhibited TNF-induced (restimulation with a high dose) IL-8 promoter-dependen...     »
Zeitschriftentitel:
J Biol Chem
Jahr:
2003
Band / Volume:
278
Heft / Issue:
26
Seitenangaben Beitrag:
23586-93
Sprache:
eng
Volltext / DOI:
doi:10.1074/jbc.M211646200
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/12707271
Print-ISSN:
0021-9258
TUM Einrichtung:
Institut für Klinische Chemie und Pathobiochemie
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