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Titel:

Optimized strategy for rapid cytochrome P450 2D6 genotyping by real-time long PCR.

Dokumenttyp:
Journal Article; Article
Autor(en):
Müller, B; Zopf, K; Bachofer, J; Steimer, W
Abstract:
BACKGROUND: Because of genetic polymorphisms, cytochrome P450 2D6 (Cyp2D6) activity in humans varies widely and alters the metabolism of commonly used drugs such as antidepressants, neuroleptics, and cardioactive agents. Severe adverse effects or resistance to therapy may result. METHODS: We performed long PCR on the LightCycler(TM) and used the product as a template for a previously validated multiplex PCR that examines the *3, *4, *6, *7, and *8 alleles of Cyp2D6. We used real-time PCR to iden...     »
Zeitschriftentitel:
Clin Chem
Jahr:
2003
Band / Volume:
49
Heft / Issue:
10
Seitenangaben Beitrag:
1624-31
Sprache:
eng
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/14500587
Print-ISSN:
0009-9147
TUM Einrichtung:
Institut für Klinische Chemie und Pathobiochemie
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