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Title:

Epigenetic regulation of Amphiregulin and Epiregulin in colorectal cancer.

Document type:
Journal Article
Author(s):
Bormann, Felix; Stinzing, Sebastian; Tierling, Sascha; Morkel, Markus; Rivera Markelova, Maria; Walter, Jörn; Weichert, Wilko; Roßner, Florian; Kuhn, Natalia; Perner, Juliane; Dietz, Johanna; Ispasanie, Sylvia; Dietel, Manfred; Schäfer, Reinhold; Heinemann, Volker; Sers, Christine
Abstract:
Expression of the epidermal growth factor ligands amphiregulin (AREG) and epiregulin (EREG) is positively correlated with a response to EGFR-targeted therapies in colorectal cancer. Gene-body methylation sites, which show a strong inverse correlation with AREG and EREG gene expression, were identified in cell lines using targeted 454 FLX-bisulfite sequencing and SIRPH analyses for AREG/EREG promoters and intragenic CpGs. Upon treatment of colorectal cancer cells with 5-aza-2'-desoxycytidine, met...     »
Journal title abbreviation:
Int J Cancer
Year:
2019
Journal volume:
144
Journal issue:
3
Pages contribution:
569-581
Language:
eng
Fulltext / DOI:
doi:10.1002/ijc.31892
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/30252132
Print-ISSN:
0020-7136
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie
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