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Title:

Nucleic acid direct delivery to fibroblasts: a review of nucleofection and applications.

Document type:
Journal Article; Review
Author(s):
Ren, Ranyue; Guo, Jiachao; Liu, Guangwu; Kang, Hao; Machens, Hans-Günther; Schilling, Arndt F; Slobodianski, Alex; Zhang, Ziyang
Abstract:
The fibroblast is one of the ideal target cell candidates for cell-based gene therapy approaches to promote tissue repair. Gene delivery to fibroblasts by viral transfection has been confirmed to have high transfection efficiency. However, in addition to immunogenic effects of viruses, the random integration of viral genes may damage the genome, affect the cell phenotype or even cause cancerous mutations in the transfected cells. Due to these potential biohazards and unknown long-term risks, the...     »
Journal title abbreviation:
J Biol Eng
Year:
2022
Journal volume:
16
Journal issue:
1
Fulltext / DOI:
doi:10.1186/s13036-022-00309-5
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/36329479
TUM Institution:
Lehrstuhl für Plastische Chirurgie und Handchirurgie (Prof. Machens)
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