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Title:

Toll-like receptor 2, hyaluronan, and neutrophils play a key role in plaque erosion: the OPTICO-ACS study.

Document type:
Journal Article
Author(s):
Meteva, Denitsa; Vinci, Ramona; Seppelt, Claudio; Abdelwahed, Youssef S; Pedicino, Daniela; Nelles, Gregor; Skurk, Carsten; Haghikia, Arash; Rauch-Kröhnert, Ursula; Gerhardt, Teresa; Straessler, Elisabeth; Zhao, Yingjie; Golla, Felix; Joner, Michael; Rai, Himanshu; Kratzer, Adelheid; Arnal, Hector Giral; Liuzzo, Giovanna; Klotsche, Jens; Crea, Filippo; Landmesser, Ulf; Leistner, David M; Kränkel, Nicolle
Abstract:
BACKGROUND AND AIMS: In one-third of patients with acute coronary syndrome (ACS), thrombosis occurs despite an intact fibrous cap (IFC) (IFC-ACS, 'plaque erosion'). Recent studies emphasize neutrophils as the immediate inflammatory response in this pathology, but their exact molecular activation patterns are still poorly understood and may represent future therapeutic targets. METHODS AND RESULTS: Thirty-two patients with IFC-ACS and matched patients with ACS with ruptured fibrous cap (RFC) (RFC...     »
Journal title abbreviation:
Eur Heart J
Year:
2023
Journal volume:
44
Journal issue:
38
Pages contribution:
3892-3907
Fulltext / DOI:
doi:10.1093/eurheartj/ehad379
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/37381760
Print-ISSN:
0195-668X
TUM Institution:
Klinik für Herz- und Kreislauferkrankungen im Erwachsenenalter (DHM) (Prof. Schunkert)
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