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Title:

Hourglass, a compass navigating global and regional heterogeneity of pancreatic cancer†.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Bakırdöğen, Derya; Görgülü, Kıvanç; Algül, Hana
Abstract:
Advances in the digital pathology field have facilitated the characterization of histology samples for both clinical and preclinical research. However, uncovering subtle correlations between bioimaging, clinical and molecular parameters requires extensive statistical analysis. As a user-friendly software, Hourglass, simplifies multiparametric dataset analysis through intuitive data visualization and statistical tools. Systemic analysis of interleukin-6 (IL-6)/pStat3 signaling pathway through Hourglass revealed differences in regional immune cell composition within tumors. Moreover, these regional disparities were partially mediated by sex. Overall, Hourglass simplifies information extraction from complex datasets, resolving overlooked regional and global spatial tumor differences. © 2024 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.
Journal title abbreviation:
J Pathol
Year:
2024
Journal volume:
263
Journal issue:
1
Pages contribution:
5-7
Fulltext / DOI:
doi:10.1002/path.6268
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/38404051
Print-ISSN:
0022-3417
TUM Institution:
Lehrstuhl für Tumormetabolismus (Prof. Algül)
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