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Titel:

Prostate-specific membrane antigen cleavage of vitamin B9 stimulates oncogenic signaling through metabotropic glutamate receptors.

Dokumenttyp:
Journal Article
Autor(en):
Kaittanis, Charalambos; Andreou, Chrysafis; Hieronymus, Haley; Mao, Ninghui; Foss, Catherine A; Eiber, Matthias; Weirich, Gregor; Panchal, Palak; Gopalan, Anuradha; Zurita, Juan; Achilefu, Samuel; Chiosis, Gabriela; Ponomarev, Vladimir; Schwaiger, Markus; Carver, Brett S; Pomper, Martin G; Grimm, Jan
Abstract:
Prostate-specific membrane antigen (PSMA) or folate hydrolase 1 (FOLH1) is highly expressed on prostate cancer. Its expression correlates inversely with survival and increases with tumor grade. However, the biological role of PSMA has not been explored, and its role in prostate cancer remained elusive. Filling this gap, we demonstrate that in prostate cancer, PSMA initiates signaling upstream of PI3K through G protein-coupled receptors, specifically via the metabotropic glutamate receptor (mGluR...     »
Zeitschriftentitel:
J Exp Med
Jahr:
2018
Band / Volume:
215
Heft / Issue:
1
Seitenangaben Beitrag:
159-175
Sprache:
eng
Volltext / DOI:
doi:10.1084/jem.20171052
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/29141866
Print-ISSN:
0022-1007
TUM Einrichtung:
Institut für Allgemeine Pathologie und Pathologische Anatomie; Klinik und Poliklinik für Nuklearmedizin
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