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Titel:

HDAC inhibitors promote intestinal epithelial regeneration via autocrine TGF?1 signalling in inflammation.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Friedrich, Marie; Gerbeth, Lorenz; Gerling, Marco; Rosenthal, Rita; Steiger, Katja; Weidinger, Carl; Keye, Jacqueline; Wu, Hao; Schmidt, Franziska; Weichert, Wilko; Siegmund, Britta; Glauben, Rainer
Abstract:
Intact epithelial barrier function is pivotal for maintaining intestinal homeostasis. Current therapeutic developments aim at restoring the epithelial barrier in inflammatory bowel disease. Histone deacetylase (HDAC) inhibitors are known to modulate immune responses and to ameliorate experimental colitis. However, their direct impact on epithelial barrier function and intestinal wound healing is unknown. In human and murine colonic epithelial cell lines, the presence of the HDAC inhibitors Givin...     »
Zeitschriftentitel:
Mucosal Immunol
Jahr:
2019
Band / Volume:
12
Heft / Issue:
3
Seitenangaben Beitrag:
656-667
Sprache:
eng
Volltext / DOI:
doi:10.1038/s41385-019-0135-7
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/30674988
Print-ISSN:
1933-0219
TUM Einrichtung:
Institut für Allgemeine Pathologie und Pathologische Anatomie
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