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Titel:

WNT enhancing signals in pancreatic cancer are transmitted by LGR6.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Wang, Jing; Koch, Dominik T; Hofmann, Felix O; Härtwig, Daniel; Beirith, Iris; Janssen, Klaus Peter; Bazhin, Alexandr V; Niess, Hanno; Werner, Jens; Renz, Bernhard W; Ilmer, Matthias
Abstract:
The G-protein-coupled receptor LGR6 associates with ligands of the R-Spondin (RSPO) family to potentiate preexisting signals of the canonical WNT pathway. However, its importance in pancreatic ductal adenocarcinoma (PDAC) remains unclear. Here, we show that LGR6 is differentially expressed in various PDAC cell lines of mesenchymal and epithelial phenotype, respectively, siding with the latter subsets. LGR6 expression is altered based upon the cells' WNT activation status. Furthermore, extrinsic...     »
Zeitschriftentitel:
Aging (Albany NY)
Jahr:
2023
Band / Volume:
15
Heft / Issue:
20
Seitenangaben Beitrag:
10897-10914
Volltext / DOI:
doi:10.18632/aging.205101
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/37770230
Print-ISSN:
1945-4589
TUM Einrichtung:
591; Klinik und Poliklinik für Chirurgie (Prof. Friess)
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