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Title:

Individualized versus standardized risk assessment in patients at high risk for adverse drug reactions (IDrug) - study protocol for a pragmatic randomized controlled trial.

Document type:
Comparative Study; Journal Article; Multicenter Study; Pragmatic Clinical Trial; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Article
Author(s):
Stingl, Julia Carolin; Kaumanns, Katharina Luise; Claus, Katrin; Lehmann, Marie-Louise; Kastenmüller, Kathrin; Bleckwenn, Markus; Hartmann, Gunther; Steffens, Michael; Wirtz, Dorothee; Leuchs, Ann-Kristin; Benda, Norbert; Meier, Florian; Schöffski, Oliver; Holdenrieder, Stefan; Coch, Christoph; Weckbecker, Klaus
Abstract:
Elderly patients are particularly vulnerable to adverse drug reactions, especially if they are affected by additional risk factors such as multimorbidity, polypharmacy, impaired renal function and intake of drugs with high risk potential. Apart from these clinical parameters, drug safety and efficacy can be influenced by pharmacogenetic factors. Evidence-based recommendations concerning drug-gene-combinations have been issued by international consortia and in drug labels. However, clinical benef...     »
Journal title abbreviation:
BMC Fam Pract
Year:
2016
Journal volume:
17
Pages contribution:
49
Language:
eng
Fulltext / DOI:
doi:10.1186/s12875-016-0447-6
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/27112273
Print-ISSN:
1471-2296
TUM Institution:
Institut für Laboratoriumsmedizin (keine SAP-Zuordnung!)
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