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Title:

Satellite 2 repeat DNA in blood plasma as a candidate biomarker for the detection of cancer.

Document type:
Article; Journal Article
Author(s):
Özgür, Emre; Mayer, Zsuzsanna; Keskin, Metin; Yörüker, Ebru E; Holdenrieder, Stefan; Gezer, Ugur
Abstract:
BACKGROUND AND AIM: Currently, cancer biomarkers are associated with low diagnostic performance, and the notion of using cell-free DNA (cfDNA) as a surrogate cancer biomarker is a subject of ongoing research efforts. Pericentromeric satellite repeats were shown to expand in tumor cells. Here, we hypothesized that the increased release of satellite DNA into the circulation might be a basis for developing a biomarker for the detection of cancer. MATERIALS AND METHODS: The study included patients w...     »
Journal title abbreviation:
Clin Chim Acta
Year:
2021
Journal volume:
514
Pages contribution:
74-79
Fulltext / DOI:
doi:10.1016/j.cca.2020.12.008
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/33333039
Print-ISSN:
0009-8981
TUM Institution:
Institut für Laboratoriumsmedizin (keine SAP-Zuordnung!)
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