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Titel:

The coffee ingredients caffeic acid and caffeic acid phenylethyl ester protect against irinotecan-induced leukopenia and oxidative stress response.

Dokumenttyp:
Article; Journal Article
Autor(en):
Kalthoff, Sandra; Paulusch, Stefan; Rupp, Alexander; Holdenrieder, Stefan; Hartmann, Gunther; Strassburg, Christian P
Abstract:
BACKGROUND AND PURPOSE: Irinotecan, used in colorectal cancer therapy, is metabolized by glucuronidation involving different UDP-glucuronosyltransferase (UGT)1A isoforms leading to facilitated elimination from the body. Individuals homozygous for the genetic variants UGT1A1*28 (Gilbert syndrome) and UGT1A7*3 are more susceptible to irinotecan side effects, severe diarrhoea and leukopenia. The aim of this study was to investigate the protective effects and active constituents of coffee during iri...     »
Zeitschriftentitel:
Br J Pharmacol
Jahr:
2020
Band / Volume:
177
Heft / Issue:
18
Seitenangaben Beitrag:
4193-4208
Volltext / DOI:
doi:10.1111/bph.15162
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/32548889
Print-ISSN:
0007-1188
TUM Einrichtung:
Institut für Laboratoriumsmedizin (keine SAP-Zuordnung!)
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