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Title:

Pharmacokinetics of tranexamic acid in neonates and infants undergoing cardiac surgery.

Document type:
Clinical Trial; Journal Article; Article
Author(s):
Gertler, Ralph; Gruber, Michael; Grassin-Delyle, Stanislas; Urien, Saïk; Martin, Klaus; Tassani-Prell, Peter; Braun, Siegmund; Burg, Simon; Wiesner, Gunther
Abstract:
Tranexamic acid (TXA) continues to be one of the antifibrinolytics of choice during paediatric cardiac surgery. However, in infants less than 1 year of age, the optimal dosing based on pharmacokinetic (PK) considerations is still under discussion.Forty-three children less than 1 year of age were enrolled, of whom 37 required the use of cardiopulmonary bypass (CPB) and six were operated on without CPB. Administration of 50 mg kg TXA intravenously at the induction of anaesthesia was followed by 50...     »
Journal title abbreviation:
Br J Clin Pharmacol
Year:
2017
Journal volume:
83
Journal issue:
8
Pages contribution:
1745-1757
Language:
eng
Fulltext / DOI:
doi:10.1111/bcp.13274
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/28245519
Print-ISSN:
0306-5251
TUM Institution:
Institut für Laboratoriumsmedizin (keine SAP-Zuordnung!)
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