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Title:

The diverse origins of circulating cell-free DNA in the human body: a critical re-evaluation of the literature

Document type:
Meeting Abstract
Author(s):
Aucamp, J; Bronkhorst, AJ; Badenhorst, CPS; Pretorius, PJ
Abstract:
Since the detection of cell-free DNA (cfDNA) in human plasma in 1948, it has been investigated as a non-invasive screening tool for many diseases, especially solid tumours and foetal genetic abnormalities. However, to date our lack of knowledge regarding the origin and purpose of cfDNA in a physiological environment has limited its use to more obvious diagnostics, neglecting, for example, its potential utility in the identification of predisposition to disease, earlier detection of cancers, and...     »
Journal title abbreviation:
Biol Rev Camb Philos Soc
Year:
2018
Journal volume:
93
Journal issue:
3
Pages contribution:
1649-1683
Language:
eng
Print-ISSN:
1464-7931
TUM Institution:
Institut für Laboratoriumsmedizin (keine SAP-Zuordnung!)
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