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Titel:

Chronic administration of XBD173 ameliorates cognitive deficits and neuropathology via 18 kDa translocator protein (TSPO) in a mouse model of Alzheimer's disease.

Dokumenttyp:
Article; Journal Article
Autor(en):
Pradhan, Arpit Kumar; Neumüller, Tatjana; Klug, Claudia; Fuchs, Severin; Schlegel, Martin; Ballmann, Markus; Tartler, Katharina Johanna; Pianos, Antoine; Garcia, Maria Sanchez; Liere, Philippe; Schumacher, Michael; Kreuzer, Matthias; Rupprecht, Rainer; Rammes, Gerhard
Abstract:
Alzheimer's disease (AD) is characterized by the accumulation of β-amyloid peptide (Aβ). It affects cognition and leads to memory impairment. The mitochondrial translocator protein (TSPO) plays an essential role in maintaining mitochondrial homeostasis and has been implicated in several neuronal disorders or neuronal injuries. Ligands targeting the mitochondrial translocator protein (18 kDa), promote neurosteroidogenesis and may be neuroprotective. To study whether the TSPO ligand XBD173 may exe...     »
Zeitschriftentitel:
Transl Psychiatry
Jahr:
2023
Band / Volume:
13
Heft / Issue:
1
Volltext / DOI:
doi:10.1038/s41398-023-02630-z
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/37891168
Print-ISSN:
2158-3188
TUM Einrichtung:
Klinik für Anästhesiologie (DHM)
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