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Dokumenttyp:
Article; Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Wolpert, Alexander; Obert, David; Frey, Birgit; Lee, Yi Shan; Korff, Sebastian
Titel:
Hepatic topographical changes of endoplasmic reticulum stress and unfolded protein response signaling after hemorrhagic shock and reperfusion.
Abstract:
BACKGROUND: Endoplasmic reticulum (ER) stress plays a crucial role in cell death decisions in context of various diseases. Although it is known that ER stress occurs in livers subjected to hemorrhagic shock and reperfusion (HS/R), there is no understanding about the influence of the liver architecture on ER stress and the activation of the unfolded protein response (UPR). MATERIALS AND METHODS: Mice were subjected to a pressure-controlled HS (30 ± 5 mmHg) for 90 min. Mice were sacrificed 2, 4, 6...     »
Zeitschriftentitel:
J Surg Res
Jahr:
2018
Band / Volume:
231
Seitenangaben Beitrag:
278-289
Volltext / DOI:
doi:10.1016/j.jss.2018.05.060
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/30278941
Print-ISSN:
0022-4804
TUM Einrichtung:
Klinik für Anästhesiologie (DHM)
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