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Titel:

The NMDA receptor antagonist Radiprodil reverses the synaptotoxic effects of different amyloid-beta (Aβ) species on long-term potentiation (LTP).

Dokumenttyp:
Article; Journal Article
Autor(en):
Rammes, Gerhard; Seeser, Franziska; Mattusch, Korinna; Zhu, Kaichuan; Haas, Laura; Kummer, Markus; Heneka, Michael; Herms, Jochen; Parsons, Chris G
Abstract:
Aβ1-42 is well accepted to be a primary early pathogenic agent in Alzheimer's disease (AD). However, other amyloid peptides are now gaining considerable attention as potential key participants in AD due to their proposed higher neuronal toxicity. Impairment of the glutamatergic system is also widely accepted to be associated with pathomechanisms underlying AD. There is ample evidence that Aβ1-42 affects GLUN2B subunit containing N-methyl-D-aspartate receptor function and abolishes the induction...     »
Zeitschriftentitel:
Neuropharmacology
Jahr:
2018
Band / Volume:
140
Seitenangaben Beitrag:
184-192
Volltext / DOI:
doi:10.1016/j.neuropharm.2018.07.021
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/30016667
Print-ISSN:
0028-3908
TUM Einrichtung:
Klinik für Anästhesiologie (DHM)
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