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Titel:

Sevoflurane mitigates shedding of hyaluronan from the coronary endothelium, also during ischemia/reperfusion: an ex vivo animal study.

Dokumenttyp:
Journal Article
Autor(en):
Chen, Congcong; Chappell, Daniel; Annecke, Thorsten; Conzen, Peter; Jacob, Matthias; Welsch, Ulrich; Zwissler, Bernhard; Becker, Bernhard F
Abstract:
Glycosaminoglycan hyaluronan (HA), a major constituent of the endothelial glycocalyx, helps to maintain vascular integrity. Preconditioning the heart with volatile anesthetic agents protects against ischemia/reperfusion injury. We investigated a possible protective effect of sevoflurane on the glycocalyx, especially on HA. The effect of pre-ischemic treatment with sevoflurane (15 minutes at 2% vol/vol gas) on shedding of HA was evaluated in 28 isolated, beating guinea pig hearts, subjected to wa...     »
Zeitschriftentitel:
Hypoxia (Auckl)
Jahr:
2016
Band / Volume:
4
Seitenangaben Beitrag:
81-90
Sprache:
eng
Volltext / DOI:
doi:10.2147/HP.S98660
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/27800510
TUM Einrichtung:
Klinik für Anästhesiologie (DHM)
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