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Title:

Desipramine targets astrocytes to attenuate synaptic plasticity via modulation of the ephrinA3/EphA4 signalling.

Document type:
Journal Article
Author(s):
Tanasic, Sascha; Mattusch, Corinna; Wagner, Eva Maria; Eder, Matthias; Rupprecht, Rainer; Rammes, Gerhard; Di Benedetto, Barbara
Abstract:
Long-term potentiation (LTP), a major cellular correlate of memory storage, depends on activation of the ERK/MAPK signalling pathway, but the cell type-specific localization of activated MAPKs remains unknown. We found that in the CA1 field of the hippocampus, shortly after LTP induction, an increase in the number of MAPK-positive cells occurred specifically among astrocytes of the stratum radiatum, suggesting a putative role of astrocytes for LTP. Desipramine (DMI) is an antidepressant which is...     »
Journal title abbreviation:
Neuropharmacology
Year:
2016
Journal volume:
105
Pages contribution:
154-63
Language:
eng
Fulltext / DOI:
doi:10.1016/j.neuropharm.2016.01.021
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/26785076
Print-ISSN:
0028-3908
TUM Institution:
Klinik für Anästhesiologie (DHM)
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