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Title:

ER stress preconditioning ameliorates liver damage after hemorrhagic shock and reperfusion.

Document type:
Article; Journal Article
Author(s):
Obert, David Peter; Wolpert, Alexander Karl; Grimm, Nathan Lewis; Korff, Sebastian
Abstract:
The mismatch of oxygen supply and demand during hemorrhagic shock disturbs endoplasmic reticulum (ER) homeostasis. The resulting accumulation of unfolded proteins in the ER lumen, which is a condition that is defined as ER stress, triggers the unfolded protein response (UPR). Since the UPR influences the extent of organ damage following hemorrhagic shock/reperfusion (HS/R) and mediates the protective effects of stress preconditioning before ischemia-reperfusion injury, the current study investig...     »
Journal title abbreviation:
Exp Ther Med
Year:
2021
Journal volume:
21
Journal issue:
3
Fulltext / DOI:
doi:10.3892/etm.2021.9679
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/33603856
Print-ISSN:
1792-0981
TUM Institution:
Klinik für Anästhesiologie (DHM)
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