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Title:

Neurosteroids and translocator protein 18 kDa (TSPO) in depression: implications for synaptic plasticity, cognition, and treatment options.

Document type:
Review; Journal Article; Review
Author(s):
Rupprecht, Rainer; Pradhan, Arpit Kumar; Kufner, Marco; Brunner, Lisa Marie; Nothdurfter, Caroline; Wein, Simon; Schwarzbach, Jens; Puig, Xenia; Rupprecht, Christian; Rammes, Gerhard
Abstract:
There is need for novel fast acting treatment options in affective disorders. 3α-reduced neurosteroids such as allopregnanolone are powerful positive allosteric modulators of GABAA receptors and target also extrasynaptic receptors. Their synthesis is mediated by the translocator protein 18 kDa (TSPO). TSPO ligands not only promote endogenous neurosteroidogenesis, but also exert a broad spectrum of functions involving modulation of mitochondrial activity and acting as anti-inflammatory and neuror...     »
Journal title abbreviation:
Eur Arch Psychiatry Clin Neurosci
Year:
2023
Journal volume:
273
Journal issue:
7
Pages contribution:
1477-1487
Fulltext / DOI:
doi:10.1007/s00406-022-01532-3
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/36574032
Print-ISSN:
0940-1334
TUM Institution:
Klinik für Anästhesiologie (DHM)
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