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Title:

Platelet regulation of myeloid suppressor of cytokine signaling 3 accelerates atherosclerosis.

Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Author(s):
Barrett, Tessa J; Schlegel, Martin; Zhou, Felix; Gorenchtein, Mike; Bolstorff, Jennifer; Moore, Kathryn J; Fisher, Edward A; Berger, Jeffrey S
Abstract:
Platelets are best known as mediators of hemostasis and thrombosis; however, their inflammatory effector properties are increasingly recognized. Atherosclerosis, a chronic vascular inflammatory disease, represents the interplay between lipid deposition in the artery wall and unresolved inflammation. Here, we reveal that platelets induce monocyte migration and recruitment into atherosclerotic plaques, resulting in plaque platelet-macrophage aggregates. In Ldlr-/- mice fed a Western diet, platele...     »
Journal title abbreviation:
Sci Transl Med
Year:
2019
Journal volume:
11
Journal issue:
517
Fulltext / DOI:
doi:10.1126/scitranslmed.aax0481
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/31694925
Print-ISSN:
1946-6234
TUM Institution:
Klinik für Anästhesiologie (DHM)
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