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Title:

Cross-disorder risk gene CACNA1C differentially modulates susceptibility to psychiatric disorders during development and adulthood.

Document type:
Journal Article
Author(s):
Dedic, N; Pöhlmann, M L; Richter, J S; Mehta, D; Czamara, D; Metzger, M W; Dine, J; Bedenk, B T; Hartmann, J; Wagner, K V; Jurik, A; Almli, L M; Lori, A; Moosmang, S; Hofmann, F; Wotjak, C T; Rammes, G; Eder, M; Chen, A; Ressler, K J; Wurst, W; Schmidt, M V; Binder, E B; Deussing, J M
Abstract:
Single-nucleotide polymorphisms (SNPs) in CACNA1C, the ?1C subunit of the voltage-gated L-type calcium channel Ca1.2, rank among the most consistent and replicable genetics findings in psychiatry and have been associated with schizophrenia, bipolar disorder and major depression. However, genetic variants of complex diseases often only confer a marginal increase in disease risk, which is additionally influenced by the environment. Here we show that embryonic deletion of Cacna1c in forebrain gluta...     »
Journal title abbreviation:
Mol Psychiatry
Year:
2018
Journal volume:
23
Journal issue:
3
Pages contribution:
533-543
Language:
eng
Fulltext / DOI:
doi:10.1038/mp.2017.133
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/28696432
Print-ISSN:
1359-4184
TUM Institution:
Institut für Pharmakologie und Toxikologie; Klinik für Anästhesiologie (DHM)
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