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Title:

In vivo mapping of pharmacologically induced functional reorganization onto the human brain's neurotransmitter landscape.

Document type:
Journal Article
Author(s):
Luppi, Andrea I; Hansen, Justine Y; Adapa, Ram; Carhart-Harris, Robin L; Roseman, Leor; Timmermann, Christopher; Golkowski, Daniel; Ranft, Andreas; Ilg, Rüdiger; Jordan, Denis; Bonhomme, Vincent; Vanhaudenhuyse, Audrey; Demertzi, Athena; Jaquet, Oceane; Bahri, Mohamed Ali; Alnagger, Naji L N; Cardone, Paolo; Peattie, Alexander R D; Manktelow, Anne E; de Araujo, Draulio B; Sensi, Stefano L; Owen, Adrian M; Naci, Lorina; Menon, David K; Misic, Bratislav; Stamatakis, Emmanuel A
Abstract:
To understand how pharmacological interventions can exert their powerful effects on brain function, we need to understand how they engage the brain's rich neurotransmitter landscape. Here, we bridge microscale molecular chemoarchitecture and pharmacologically induced macroscale functional reorganization, by relating the regional distribution of 19 neurotransmitter receptors and transporters obtained from positron emission tomography, and the regional changes in functional magnetic resonance imag...     »
Journal title abbreviation:
Sci Adv
Year:
2023
Journal volume:
9
Journal issue:
24
Fulltext / DOI:
doi:10.1126/sciadv.adf8332
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/37315149
Print-ISSN:
2375-2548
TUM Institution:
Klinik für Anästhesiologie (DHM); Klinik und Poliklinik für Neurologie (Prof. Hemmer)
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