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Titel:

Systemic inflammation leads to resistance to atracurium without increasing membrane expression of acetylcholine receptors.

Dokumenttyp:
Journal Article; Article
Autor(en):
Fink, H; Luppa, P; Mayer, B; Rosenbrock, H; Metzger, J; Martyn, JA; Blobner, M
Abstract:
BACKGROUND: Systemic inflammation may be associated with resistance to nondepolarizing neuromuscular blocking drugs, the mechanisms of which are, however, uncharacterized. The authors therefore investigated the pharmacodynamics of atracurium and its relation to the expression of nicotinic acetylcholine receptors and alpha1 -acid glycoprotein in a rat model of systemic inflammation. METHODS: To induce a systemic inflammation, male CD rats received 56 mg/kg corynebacterium parvum intravenously. On...     »
Zeitschriftentitel:
Anesthesiology
Jahr:
2003
Band / Volume:
98
Heft / Issue:
1
Seitenangaben Beitrag:
82-8
Sprache:
eng
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/12502983
Print-ISSN:
0003-3022
TUM Einrichtung:
Institut für Klinische Chemie und Pathobiochemie; Klinik für Anästhesiologie (DHM)
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