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Titel:

Neurosteroids and translocator protein 18 kDa (TSPO) in depression: implications for synaptic plasticity, cognition, and treatment options.

Dokumenttyp:
Review; Journal Article; Review
Autor(en):
Rupprecht, Rainer; Pradhan, Arpit Kumar; Kufner, Marco; Brunner, Lisa Marie; Nothdurfter, Caroline; Wein, Simon; Schwarzbach, Jens; Puig, Xenia; Rupprecht, Christian; Rammes, Gerhard
Abstract:
There is need for novel fast acting treatment options in affective disorders. 3α-reduced neurosteroids such as allopregnanolone are powerful positive allosteric modulators of GABAA receptors and target also extrasynaptic receptors. Their synthesis is mediated by the translocator protein 18 kDa (TSPO). TSPO ligands not only promote endogenous neurosteroidogenesis, but also exert a broad spectrum of functions involving modulation of mitochondrial activity and acting as anti-inflammatory and neuror...     »
Zeitschriftentitel:
Eur Arch Psychiatry Clin Neurosci
Jahr:
2023
Band / Volume:
273
Heft / Issue:
7
Seitenangaben Beitrag:
1477-1487
Volltext / DOI:
doi:10.1007/s00406-022-01532-3
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/36574032
Print-ISSN:
0940-1334
TUM Einrichtung:
Klinik für Anästhesiologie (DHM)
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