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Titel:

Meta-analyses identify DNA methylation associated with kidney function and damage.

Dokumenttyp:
Article; Journal Article
Autor(en):
Schlosser, Pascal; Tin, Adrienne; Matias-Garcia, Pamela R; Thio, Chris H L; Joehanes, Roby; Liu, Hongbo; Weihs, Antoine; Yu, Zhi; Hoppmann, Anselm; Grundner-Culemann, Franziska; Min, Josine L; Adeyemo, Adebowale A; Agyemang, Charles; Ärnlöv, Johan; Aziz, Nasir A; Baccarelli, Andrea; Bochud, Murielle; Brenner, Hermann; Breteler, Monique M B; Carmeli, Cristian; Chaker, Layal; Chambers, John C; Cole, Shelley A; Coresh, Josef; Corre, Tanguy; Correa, Adolfo; Cox, Simon R; de Klein, Niek; Delgado, Gra...     »
Abstract:
Chronic kidney disease is a major public health burden. Elevated urinary albumin-to-creatinine ratio is a measure of kidney damage, and used to diagnose and stage chronic kidney disease. To extend the knowledge on regulatory mechanisms related to kidney function and disease, we conducted a blood-based epigenome-wide association study for estimated glomerular filtration rate (n = 33,605) and urinary albumin-to-creatinine ratio (n = 15,068) and detected 69 and seven CpG sites where DNA methylation...     »
Zeitschriftentitel:
Nat Commun
Jahr:
2021
Band / Volume:
12
Heft / Issue:
1
Volltext / DOI:
doi:10.1038/s41467-021-27234-3
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/34887417
Print-ISSN:
2041-1723
TUM Einrichtung:
273; Institut für Humangenetik; Klinik für Herz- und Kreislauferkrankungen im Erwachsenenalter (Prof. Schunkert); Lehrstuhl für Neurogenetik (Prof. Winkelmann)
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