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- Title:
Stent malapposition and the risk of stent thrombosis: mechanistic insights from an in vitro model.
- Document type:
- journal article
- Author(s):
- Foin, Nicolas; Lu, Shengjie; Ng, Jaryl; Bulluck, Heerajnarain; Hausenloy, Derek J; Wong, Philip E; Virmani, Renu; Joner, Michael
- Abstract:
- The aim of this report was to examine the effect of underexpansion on stent thrombogenicity with an in vitro perfusion model.Drug-eluting stent (DES) samples were partially underdeployed in silicone tubes and perfused with porcine blood containing 10% anticoagulant citrate dextrose solution for four minutes at a flow rate of 200 ml/min. Thrombus formation was evaluated and compared between the well-apposed and malapposed sections. The malapposed sections showed significantly more thrombus formation compared to the well-apposed sections (13.9 vs. 0.41 mm2, p<0.001).Stent malapposition has a very direct impact on thrombus formation. Optimised stent implantation is required to minimise malapposition in DES and BVS to reduce thrombus formation.
- Journal title abbreviation:
- EuroIntervention
- Year:
- 2017
- Journal volume:
- 13
- Journal issue:
- 9
- Pages contribution:
- e1096-e1098
- Language:
- eng
- Fulltext / DOI:
- doi:10.4244/EIJ-D-17-00381
- Pubmed ID:
- http://view.ncbi.nlm.nih.gov/pubmed/28781241
- Print-ISSN:
- 1774-024X
- TUM Institution:
- Klinik für Herz- und Kreislauferkrankungen
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