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Title:

Stent malapposition and the risk of stent thrombosis: mechanistic insights from an in vitro model.

Document type:
journal article
Author(s):
Foin, Nicolas; Lu, Shengjie; Ng, Jaryl; Bulluck, Heerajnarain; Hausenloy, Derek J; Wong, Philip E; Virmani, Renu; Joner, Michael
Abstract:
The aim of this report was to examine the effect of underexpansion on stent thrombogenicity with an in vitro perfusion model.Drug-eluting stent (DES) samples were partially underdeployed in silicone tubes and perfused with porcine blood containing 10% anticoagulant citrate dextrose solution for four minutes at a flow rate of 200 ml/min. Thrombus formation was evaluated and compared between the well-apposed and malapposed sections. The malapposed sections showed significantly more thrombus formation compared to the well-apposed sections (13.9 vs. 0.41 mm2, p<0.001).Stent malapposition has a very direct impact on thrombus formation. Optimised stent implantation is required to minimise malapposition in DES and BVS to reduce thrombus formation.
Journal title abbreviation:
EuroIntervention
Year:
2017
Journal volume:
13
Journal issue:
9
Pages contribution:
e1096-e1098
Language:
eng
Fulltext / DOI:
doi:10.4244/EIJ-D-17-00381
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/28781241
Print-ISSN:
1774-024X
TUM Institution:
Klinik für Herz- und Kreislauferkrankungen
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