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Titel:

Fractalkine is expressed in early and advanced atherosclerotic lesions and supports monocyte recruitment via CX3CR1.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Stolla, M; Pelisek, J; von Brühl, ML; Schafer, A; Barocke, V; Heider, P; Lorenz, M; Tirniceriu, A; Steinhart, A; Bauersachs, J; Bray, PF; Massberg, S; Schulz, C
Abstract:
Fractalkine (CX3CL1, FKN) is expressed in the inflamed vascular wall and absence of FKN reduces atherogenesis. Whether FKN is expressed throughout all stages of atherosclerotic disease and whether it directly contributes to monocyte recruitment to atherosclerotic lesions is not known. We collected human atherosclerotic plaque material and blood samples from patients with carotid artery disease undergoing endarterectomy. Plaques were analyzed by immunohistochemistry and qPCR. We found that FKN is...     »
Zeitschriftentitel:
PLoS ONE
Jahr:
2012
Band / Volume:
7
Heft / Issue:
8
Seitenangaben Beitrag:
e43572
Sprache:
eng
Volltext / DOI:
doi:10.1371/journal.pone.0043572
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/22916279
Print-ISSN:
1932-6203
TUM Einrichtung:
Fachgebiet Gefäßchirurgie (Prof. Eckstein); Klinik für Herz- und Kreislauferkrankungen im Erwachsenenalter (Prof. Schunkert)
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