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Titel:

Distinct epigenetic programs regulate cardiac myocyte development and disease in the human heart in vivo.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Gilsbach, Ralf; Schwaderer, Martin; Preissl, Sebastian; Grüning, Björn A; Kranzhöfer, David; Schneider, Pedro; Nührenberg, Thomas G; Mulero-Navarro, Sonia; Weichenhan, Dieter; Braun, Christian; Dreßen, Martina; Jacobs, Adam R; Lahm, Harald; Doenst, Torsten; Backofen, Rolf; Krane, Markus; Gelb, Bruce D; Hein, Lutz
Abstract:
Epigenetic mechanisms and transcription factor networks essential for differentiation of cardiac myocytes have been uncovered. However, reshaping of the epigenome of these terminally differentiated cells during fetal development, postnatal maturation, and in disease remains unknown. Here, we investigate the dynamics of the cardiac myocyte epigenome during development and in chronic heart failure. We find that prenatal development and postnatal maturation are characterized by a cooperation of act...     »
Zeitschriftentitel:
Nat Commun
Jahr:
2018
Band / Volume:
9
Heft / Issue:
1
Seitenangaben Beitrag:
391
Sprache:
eng
Volltext / DOI:
doi:10.1038/s41467-017-02762-z
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/29374152
Print-ISSN:
2041-1723
TUM Einrichtung:
Klinik für Herz- und Gefäßchirurgie (Prof. Lange)
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