Clostridioides (Clostridium) difficile Pacemaker Infection.

Berkefeld, Anna; Berger, Fabian K; Gärtner, Barbara C; Wantia, Nina; Prinzing, Anatol; Laugwitz, Karl-Ludwig; Busch, Dirk H; Rothe, Kathrin

doi:10.1093/ofid/ofaa487

Klinik für Herz- und Gefäßchirurgie (DHM) (Prof. Krane)

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Title:: Clostridioides (Clostridium) difficile Pacemaker Infection.
Document type:: Article; Case Reports
Author(s):: Berkefeld, Anna; Berger, Fabian K; Gärtner, Barbara C; Wantia, Nina; Prinzing, Anatol; Laugwitz, Karl-Ludwig; Busch, Dirk H; Rothe, Kathrin
Abstract:: Clostridioides difficile is the leading cause of antibiotic-associated nosocomial diarrhea, but extra-intestinal manifestations are rare. We describe the first documented case of bacteraemia with pacemaker pocket and lead infection with the toxigenic C. difficile ribotype 014 with a lack of abdominal symptoms. The patient underwent pacemaker extraction and treatment with intravenous and oral vancomycin. Genotyping and molecular subtyping revealed clonality between pacemaker and intestinal isolates. This case illustrates the risk of intravascular device infections due to C. difficile. Even asymptomatic C. difficile colonization might pose a risk for prosthetic material infection. «
Clostridioides difficile is the leading cause of antibiotic-associated nosocomial diarrhea, but extra-intestinal manifestations are rare. We describe the first documented case of bacteraemia with pacemaker pocket and lead infection with the toxigenic C. difficile ribotype 014 with a lack of abdominal symptoms. The patient underwent pacemaker extraction and treatment with intravenous and oral vancomycin. Genotyping and molecular subtyping revealed clonality between pacemaker and intestinal isolat... »
Journal title abbreviation:: Open Forum Infect Dis
Year:: 2020
Journal volume:: 7
Journal issue:: 12
Fulltext / DOI:: doi:10.1093/ofid/ofaa487
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/33324719
TUM Institution:: I. Medizinische Klinik und Poliklinik (Kardiologie); Institut für Medizinische Mikrobiologie, Immunologie und Hygiene; Klinik für Herz- und Gefäßchirurgie (Prof. Lange)
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