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Titel:

Voxel-based morphometry indicates relative preservation of the limbic prefrontal cortex in early Huntington disease.

Dokumenttyp:
Journal Article; Article
Autor(en):
Muhlau, M; Weindl, A; Wohlschläger, AM; Gaser, C; Städtler, M; Valet, M; Zimmer, C; Kassubek, J; Peinemann, A
Abstract:
In Huntington disease (HD), both the genetic defect and mutant gene product huntington are known but the exact mechanisms that lead to neuronal loss are poorly understood. Until now, the distribution of tissue loss throughout the brain has been investigated intensively. Here we searched for areas that, antipodal to the striatum, display grey-matter (GM) preservation. We performed high resolution T1-weighted magnetic resonance imaging and voxel-based morphometry in 46 patients in early HD and 46...     »
Zeitschriftentitel:
J Neural Transm
Jahr:
2007
Band / Volume:
114
Heft / Issue:
3
Seitenangaben Beitrag:
367-72
Sprache:
eng
Volltext / DOI:
doi:10.1007/s00702-006-0571-x
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/17024326
Print-ISSN:
0300-9564
TUM Einrichtung:
Fachgebiet Neuroradiologie (Prof. Zimmer); Neurologische Klinik und Poliklinik
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