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Title:

Spectral Dynamics of Resting State fMRI Within the Ventral Tegmental Area and Dorsal Raphe Nuclei in Medication-Free Major Depressive Disorder in Young Adults.

Document type:
Journal Article
Author(s):
Wohlschläger, Afra; Karne, Harish; Jordan, Denis; Lowe, Mark J; Jones, Stephen E; Anand, Amit
Abstract:
Background: Dorsal raphe nucleus (DRN) and ventral tegmental area (VTA) are major brainstem monamine nuclei consisting of serotonin and dopamine neurons respectively. Animal studies show that firing patterns in both nuclei are altered when animals exhibit depression like behaviors. Functional MRI studies in humans have shown reduced VTA activation and DRN connectivity in depression. This study for the first time aims at investigating the functional integrity of local neuronal firing concurrently...     »
Journal title abbreviation:
Front Psychiatry
Year:
2018
Journal volume:
9
Fulltext / DOI:
doi:10.3389/fpsyt.2018.00163
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/29867598
TUM Institution:
Fachgebiet Neuroradiologie (Prof. Zimmer)
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