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Title:

Iodine Images in Dual-energy CT: Detection of Hepatic Steatosis by Quantitative Iodine Concentration Values.

Document type:
Journal Article
Author(s):
Beck, Stefanie; Jahn, Laurenz; Deniffel, Dominik; Riederer, Isabelle; Sauter, Andreas; Makowski, Marcus R; Pfeiffer, Daniela
Abstract:
Hepatic steatosis is a common condition and an early manifestation of a systemic metabolic syndrome. As of today, there is no broadly accepted method for the diagnosis of hepatic steatosis in contrast-enhanced CT images. This retrospective study evaluates the potential of quantitative iodine values in portal venous phase iodine images in dual-energy CT (DECT) by measuring iodine concentrations in regions of interest (ROI) and analyzing the absolute iodine concentration of the liver parenchyma as well as three different blood-normalized iodine concentrations in a study cohort of 251 patients. An independent two sample t-test (p < 0.05) was used to compare the iodine concentrations of healthy and fatty liver. Diagnostic performance was assessed by ROC (receiver operating characteristic) curve analysis. The results showed significant differences between the average iodine concentration of healthy and fatty liver parenchyma for the absolute and for the blood-normalized iodine concentrations. The study concludes that the iodine uptake of the liver parenchyma is impaired by hepatic steatosis, and that the measurement of iodine concentration can provide a suitable method for the detection of hepatic steatosis in quantitative iodine images. Suitable thresholds of quantitative iodine concentration values for the diagnosis of hepatic steatosis are provided.
Journal title abbreviation:
J Digit Imaging
Year:
2022
Journal volume:
35
Journal issue:
6
Pages contribution:
1738-1747
Fulltext / DOI:
doi:10.1007/s10278-022-00682-z
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/35879495
Print-ISSN:
0897-1889
TUM Institution:
Institut für Diagnostische und Interventionelle Radiologie (Prof. Makowski); Professur für Neuroradiologie (Prof. Zimmer)
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